GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7582720 | 1 | rs6725887 | chr2:203745885 | ALS2CR8 | chr2:203776978-203851060:+ | 0.28 | 5.75 | 1.58E-8 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs6725887 | chr2:203745885 | ICA1L | chr2:203637873-203736371:- | -0.22 | -3.76 | 0.000194 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs6726292 | 1 | rs6726292 | chr2:55156630 | RPL23AP32 | chr2:54756359-54756978:+ | 0.19 | 3.48 | 0.00055 | Obesity (extreme) |
| THCA | cis | rs6726292 | 1 | rs6726292 | chr2:55156630 | RTN4 | chr2:55199329-55277734:- | 0.26 | 5.32 | 1.58E-7 | Obesity (extreme) |
| THCA | cis | rs11888559 | 1 | rs6727994 | chr2:204157238 | ALS2CR8 | chr2:203776978-203851060:+ | -0.25 | -3.88 | 0.00012 | Height |
| THCA | cis | rs4665809 | 1 | rs6729080 | chr2:26301282 | GPR113 | chr2:26531041-26569685:- | -0.45 | -7.05 | 6.34E-12 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6729757 | chr2:26285102 | GPR113 | chr2:26531041-26569685:- | -0.44 | -7.03 | 7.11E-12 | Gut microbiome composition (summer) |
| THCA | cis | rs4665809 | 1 | rs6729757 | chr2:26285102 | HADHA | chr2:26413505-26467594:- | -0.16 | -3.34 | 0.000904 | Gut microbiome composition (summer) |
| THCA | cis | rs2041840 | 1 | rs6730503 | chr2:37528478 | CEBPZ | chr2:37428778-37458740:- | 0.18 | 4.01 | 6.97E-5 | Chronic lymphocytic leukemia |
| THCA | cis | rs13182402 | 1 | rs67308532 | chr5:125908599 | ALDH7A1 | chr5:125878918-125931082:- | 0.44 | 6.2 | 1.25E-9 | Osteoporosis |
| THCA | cis | rs6430585 | 1 | rs6732236 | chr2:136501509 | DARS | chr2:136664254-136743222:- | 0.37 | 6.68 | 6.84E-11 | Corneal structure |
| THCA | cis | rs17321999 | 1 | rs6732241 | chr2:30479927 | LBH | chr2:30454397-30482899:+ | -0.18 | -3.4 | 0.000721 | Systemic lupus erythematosus |
| THCA | cis | rs7577851 | 1 | rs67325097 | chr2:69725982 | AAK1 | chr2:69685127-69870977:- | -0.22 | -4.56 | 6.61E-6 | Parkinson's disease (age of onset) |
| THCA | cis | rs7577851 | 1 | rs67325097 | chr2:69725982 | NFU1 | chr2:69623255-69664753:- | -0.16 | -3.55 | 0.000431 | Parkinson's disease (age of onset) |
| THCA | cis | rs67335251 | 1 | rs67335251 | chr16:4071722 | NAT15 | chr16:3493668-3536962:+ | -0.32 | -3.76 | 0.000192 | Diisocyanate-induced asthma |